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Direct-to-Implant vs. Autologous Tissue Transfer: A meta-analysis of patient reported outcomes after immediate breast reconstruction.

      Abstract

      Background

      The effect of immediate implant and autologous breast reconstruction on patient complication rates has been studied extensively, but patient-reported outcomes for these procedures during immediate, one-stage reconstruction has yet to be comprehensively investigated.

      Objective

      This study compares patient-reported outcomes for immediate implant reconstruction with immediate autologous reconstruction to determine advantages and disadvantages for each surgical modality from the patient’s perspective.

      Methods

      A literature search of PubMed between 2010 and 2021 was performed, and 21 studies containing patient-reported outcomes were selected for analysis. Meta-analysis of patient-reported outcome scores was performed separately for immediate breast reconstruction using autologous tissue transfer and synthetic implants.

      Results

      Nineteen manuscripts were included in the analysis of breast satisfaction representing data on a total of 1,342 patients across all studies. The pooled mean of patients’ satisfaction with their breasts was 70.7 (95% CI, 69.4-72.0) after immediate autologous reconstruction and 68.5 (95% CI, 67.1-69.9) after immediate implant reconstruction, showing a statistically significant difference in outcome (p<0.05). The pooled mean of patients’ sexual well-being was 59.3 (95% CI, 57.8-60.8) after immediate autologous reconstruction and 62.8 (95% CI, 60.7-64.8) after immediate implant reconstruction (p<0.01). The pooled mean of patients’ satisfaction with their outcome was 78.8 (95% CI, 76.2-81.3) after immediate autologous reconstruction and 82.3 (95% CI, 80.4-84.1) after immediate implant reconstruction (p<0.05). The results of each meta-analysis were summarized on forest plots depicting the distribution of patient-reported outcome scores from each study.

      Conclusions

      Immediate reconstruction with implants may have a similar or greater capacity to achieve patient satisfaction and improve QoL compared to immediate reconstruction with autologous tissue transfer when both procedures are an option.

      Keywords

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