Correspondence and Communications| Volume 79, P55-57, April 2023

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A perioperative protocol for the management of patent blue V dye-induced hypersensitivity reaction during sentinel lymph node biopsy for cutaneous melanoma

Published:February 04, 2023DOI:
      Regional lymph node status in melanoma is an important prognostic factor, where nodal disease carries a less favorable prognosis than localized disease. The sentinel lymph node (SLN) is the first regional lymph node draining the tumor and represents the first site of possible lymphatic metastasis. Sentinel lymph node biopsy (SLNB) for melanoma can be performed using pre-operative lymphoscintigraphy and intra-operative gamma-probe detection or visual identification using an injected dye. A commonly used dye for melanoma in Europe is Patent Blue V (PBV) [Laboratoire Guerbert, Aulnay-Sous-Bois, France]. Its medical use however carries several potential drawbacks, including allergic reactions.
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