Adipose-derived stem cells exosome and its potential applications in autologous fat grafting

  • Yuxin Zhang
    Department of Plastic Surgery, Huadong Hospital, Fudan University, Shanghai, China

    Shanghai Medical College of Fudan University, Shanghai, China
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  • Tianyi Liu
    Corresponding author at: Department of Plastic Surgery, Huadong Hospital, Fudan University, 221 Yan 'an West Road, Jing 'an District, Shanghai, China 200040.
    Department of Plastic Surgery, Huadong Hospital, Fudan University, Shanghai, China
    Search for articles by this author
Published:November 01, 2022DOI:


      Recently, there has been renewed interest in autologous fat grafting both for its filler and regenerative traits. The universal application, however, has been impeded by the unstable survival rates and complications. There has been substantial research undertaken on the role of adipose-derived stem cells (ADSCs) involved in fat graft fates including angiogenesis, adipogenesis, and inflammatory regulation. As the effectors of their parental cells, ADSC-derived exosomes (ADSC-exos) encapsulating multiple bioactive cargoes mediate cell-to-cell communication in a paracrine manner. ADSC-exos have received much attention for their biocompatible and efficient therapeutic potentials as “cell-free therapy” in plastic surgery, including increasing fat grafting survival rates. In this review, we summarize the current knowledge about the biological basis of ADSC-exos, ADSC-related mechanisms of fat survival, research updates of ADSC-exos in autologous fat grafting, and discuss some challenges along with research prospects.


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