Abstract
The accumulation of submental fat (SMF) can negatively impact facial harmony appearance,
and one alternative treatment for this condition is the application of deoxycholic
acid (DOC). The objective of this systematic review was to answer the following question:
“Is DOC able to reduce SMF and increase patient satisfaction when compared to the
placebo groups?”. Therefore, a detailed search strategy was carried out in 6 scientific
databases (PubMed, Scopus, Embase, Lilacs, SciELO, and Web of Science) as primary
search sources, while OpenGrey and OpenThesis were also used to capture the “grey
literature”. Only six studies met all inclusion criteria and were considered in this
review analysis. The selected sample included prospective clinical studies published
from 2014 to 2018, covering a total sample of 3488 patients, with an average age ranging
from 46 to 49.5 years old. All selected articles evaluated the effect of DOC at concentrations
of 1 mg/cm² or 2 mg/cm², using saline or placebo as control solutions for the comparative
analysis. The application interval was 28 days in all studies analyzed, and the treatment
duration ranged from 4 to 6 weeks. In all studies evaluated, there was a reduction
in SMF and patient satisfaction with the application of DOC was higher than in the
control groups at the end of a 12-week period. Thus, it is possible to conclude that
the application of DOC has a positive effect on reducing SMF and improving patient
satisfaction concerning their facial appearance.
Keywords
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References
- ATX-101 for reduction of submental fat: A phase III randomized controlled trial.J Am Acad Dermatol. 2016; 75: 788-797
- Assessing the Efficacy of Deoxycholic Acid for the Treatment of Submental Fat: A Three-Dimensional Study.Aesthet Surg J. 2019; 39: 1400-1411
- Deoxycholic Acid and the Marginal Mandibular Nerve: A Cadaver Study.Aesthetic Plast Surg. 2018; 42: 1394-1398
- Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution.Dermatol Surg. 2004; 30: 1001-1008
- Efficacy, patient-reported outcomes and safety profile of ATX-101 (deoxycholic acid), an injectable drug for the reduction of unwanted submental fat: results from a phase III, randomized, placebo-controlled study.J Eur Acad Dermatol Venereol. 2014; 28: 1707-1715
- Management of Patient Experience With ATX-101 (Deoxycholic Acid Injection) for Reduction of Submental Fat [published correction appears in Dermatol Surg 2017;43;1000].Dermatol Surg. 2016; 42: S288-S299
- Reduction of Submental Fat Continues Beyond 28 Days After ATX-101 Treatment: Results from a Post hoc Analysis.Dermatol Surg. 2018; 44: 1477-1479
- The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.BMJ (Clinical Research ed.). 2009; : 339
Cochrane Handbook for systematic Reviews of Interventions. Second Edition, Oxford, UK, 2019.
- Chapter 7: Systematic reviews of etiology and risk.JBI Manual for Evidence Synthesis. 2020;
- Reduction of unwanted submental fat with ATX-101 (deoxycholic acid), an adipocytolytic injectable treatment: results from a phase III, randomized, placebo-controlled study.Br J Dermatol. 2014; 170: 445-453
- Results from a pooled analysis of two European, randomized, placebo-controlled, phase 3 studies of ATX-101 for the pharmacologic reduction of excess submental fat.Aesthetic Plast Surg. 2014; 38: 849-860
- REFINE-1, a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial With ATX-101, an Injectable Drug for Submental Fat Reduction.Dermatol Surg. 2016; 42: 38-49
- Overview of ATX-101 (Deoxycholic Acid Injection): A Nonsurgical Approach for Reduction of Submental Fat.Dermatol Surg. 2016; 42: S263-S270
- Adverse Events of Injectable Deoxycholic Acid.Dermatol Surg. 2020; 46: 942-949
- A template for estimating doses of deoxycholic acid for submental fat fullness.J Am Acad Dermatol. 2016; 75: e151-e152
- Clinical trials (phase III) - profile of scientific publications. Bioethical aspects.Rev Bras Clin Med. 2010; 8: 143-147
Article info
Publication history
Published online: August 17, 2022
Accepted:
August 1,
2022
Received:
January 13,
2022
Identification
Copyright
© 2022 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
