Summary
Distraction osteogenesis (DO) is a widely used technique in plastic and orthopaedic
surgery. During the process, mechanical force is applied to fractured bone to enhance
the regenerative processes and induce new bone formation.
Although there is an abundance of literature on the clinical process of DO, there
is a distinct lack of focus on the underlying biological principles governing this
process. DO follows the basic premises of tissue engineering. The mechanical stress
stimulates mesenchymal stem cell differentiation down an osteoblastic lineage on a
matrix background. The aim of this review is to give an overview of the current knowledge
of the molecular mechanism governing this process.
Keywords
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Article info
Publication history
Published online: November 25, 2015
Accepted:
November 14,
2015
Received:
May 18,
2015
Identification
Copyright
© 2015 Published by Elsevier Inc. All rights reserved.
