Summary
Stromal Vascular Fraction (SVF) is a heterogeneous collection of cells contained within
adipose tissue that is traditionally isolated using enzymes such as collagenase. With
the removal of adipose cells, connective tissue and blood from lipoaspirate, comes
the SVF, a mix including mesenchymal stem cells, endothelial precursor cells, T regulatory
cells, macrophages, smooth muscle cells, pericytes and preadipocytes. In part 1 of
our 2-part series, we review the literature with regards to the intensifying interest
that has shifted toward this mixture of cells, particularly due to its component synergy
and translational potential. Trials assessing the regenerative potential of cultured
Adipose Derived Stem Cells (ADSCs) and SVF demonstrate that SVF is comparably effective
in treating conditions ranging from radiation injuries, burn wounds and diabetes,
amongst others. Aside from their use in chronic conditions, SVF enrichment of fat
grafts has proven a major advance in maintaining fat graft volume and viability. Many
SVF studies are currently in preclinical phases or are moving to human trials. Overall,
regenerative cell therapy based on SVF is at an early investigative stage but its
potential for clinical application is enormous.
Keywords
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Article info
Publication history
Published online: October 30, 2015
Accepted:
October 13,
2015
Received:
April 14,
2015
Identification
Copyright
© 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Inc. All rights reserved.
