Summary
Background
Stem cell enrichment is generally believed to be of crucial importance for success
in lipofilling for cosmetic breast augmentation. No comparative clinical studies have
been reported to support this.
Methods
A total of 18 women underwent breast augmentation with water-assisted lipotransfer
(WAL). In 10 of the cases, transferred lipoaspirate was enriched with stromal stem
cells using the Celution® system (Cytori Therapeutics Inc., San Diego, Ca, USA). Magnetic resonance imaging
(MRI)-based volumetric analysis was done preoperatively and 6 months after the procedure.
To verify scientifically that stem cells were transplanted, samples of the transplanted
tissues were processed in the laboratory to isolate the adipose stem cells (ASCs).
Results
MRI volumetry revealed a volume survival of the whole (watery) graft of mean 54% (SD 7)
in the WAL only and of 50% (SD 10) in the WAL with stem cell-enrichment patients.
As centrifugation of the WAL grafts demonstrated an average adipose tissue of 68%,
the average volume survival of adipose tissue itself was 79% (SD 13) in the WAL only
and 74% (SD 14) in the WAL with stem cell-enrichment patients. This difference (4.5%)
was not statistically significant (independent samples t test, p = 0.330, 95% confidence interval of difference, 4.8, 13.9%).
Conclusions
Breast augmentation by lipofilling using WAL alone is faster, cheaper, has a lower
risk of contamination and offers at least an equal take rate. We do not see any advantage
in stem cell enrichment by the Celution® system in cosmetic fat transplantation to the breast.
Keywords
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Article Info
Publication History
Published online: July 10, 2013
Accepted:
June 3,
2013
Received:
January 17,
2013
Footnotes
☆Attributed to Department of Plastic Surgery, Tampere University Hospital, PL 2000, 33521, Tampere, Finland.
☆☆The work has been partially presented in the following congresses: 43. Jahrestagung der DGPRÄC (Deutsche Gesellschaft der Plastischen, Rekonstruktiven und Ästetischen Chirurgen e.V.) and 17. Jahrestagung der VDÄPC (Vereinigung der Deutschen Ästetisch-Plastischen Chirurgen e.V.), Bremen 13–15 September 2012; Marrakech World Aesthetic Congress, Marrakech, 9–10 November 2012; 7th Berlin International Workshop on Breast Augmentation and Reconstruction by Lipotransfer – BEAULI, Berlin 16 June 2012.
Identification
Copyright
© 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Inc. All rights reserved.
