Summary
Background
There has been limited reported experience with the use of Strattice™ (LifeCell Corp.,
Branchburg, NJ), a porcine-derived acellular dermal matrix, in implant-based breast
reconstruction. The purpose of this study is to evaluate our experience with this
matrix.
Methods
Patients who underwent immediate single-stage or two-stage implant-based breast reconstruction
with the assistance of Strattice were included in this study. Patient charts were
reviewed for indications for mastectomy, adjunctive radiotherapy use, implant or expander
volume, length of follow-up period, and type and incidence of complications during
the follow-up period. Biopsies of Strattice were taken for histological analyses.
Results
A total of 105 reconstructions were performed in 54 patients: 77% were prophylactic
and 23% were oncologic. All, but 4, reconstructions were single stage. Mean implant
volume of single-stage reconstructions were 444.1 (range: 150–700 cc) and mean expander
volume after completion of expansion was 400 (range: 350–450). Mean follow-up period
was 41.3 months (range: 35.5–48.4 months). Total complication rate was 8.6%. Complications
occurred in 9 breasts: implant loss or explantation (3.8%), infection (3.8%), skin
breakdown or necrosis (2.9%), seroma (1.9%), implant exposure (1.0%), and delayed
skin healing (1.0%). Histological analyses of implanted Strattice revealed a viable
matrix with fibroblast infiltration and revascularization.
Conclusions
Over a mean 3.5-year follow-up period, low complication rates and good outcomes were
observed with the use of Strattice that are comparable to those reported with human
acellular dermal matrices.
Keywords
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Article info
Publication history
Published online: November 14, 2012
Accepted:
October 21,
2012
Received:
April 26,
2012
Identification
Copyright
© 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Inc. All rights reserved.
