Case report| Volume 65, ISSUE 5, e121-e123, May 2012

Follicular hyperplasia – A rare differential to metastatic malignant melanoma

Published:February 15, 2012DOI:


      The assumption in a patient with a history of melanoma is that any subsequent lymphadenopathy is metastatic disease. We present a case where a seemingly obvious case of metastatic malignant melanoma proved to be Reactive Follicular Hyperplasia, illustrating it is important to be aware of all differential diagnoses, even when a cause appears obvious.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Plastic, Reconstructive & Aesthetic Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Marsden J.R.
        • Newton-Bishop J.A.
        • Burrows L.
        • et al.
        Revised UK guidelines for the management of cutaneous melanoma 2010.
        J Plast Reconstr Aesthetic Surg. 2010; 63: 1401-1419
        • Ioachim H.L.
        • Ratech H.
        Iaochim’s lymph node pathology.
        Lippincott Williams & Wilkins, Philadelphia2002
        • Sternberg S.S.
        Histology for pathologists.
        Lippincott-Raven, Philadelphia/New York2006
      1. MacSween R.N.M. Whaley K. Muir’s Textbook of Pathology. 13th ed. Edward Arnold, London1992
        • Rosai J.
        Rosai and Ackerman’s surgical pathology.
        9th ed. Mosby, 2004
        • Rappaport H.
        • Winter W.J.
        • Hicks E.B.
        Follicular lymphoma. A reevaulation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases.
        Cancer. 1956; 9: 792-821
        • Nathwani B.N.
        • Winberg C.D.
        • Diamond L.W.
        • Bearman R.M.
        • Kim H.
        Morphologic criteria for the differentiation of follicular lymphoma from florid reactive hyperplasia. A study of 80 cases.
        Cancer. 1981; 48: 1794-1806
        • Kondo E.
        • Nakamura S.
        • Onoue H.
        • et al.
        Detection of bcl-2 protein and bcl-2 messenger RNA in normal and neoplastic lymphoid tissues by immunohistochemistry and in situ hybridization.
        Blood. 1992; 80: 2044-2051
        • Newton Bishop J.A.
        • Corrie P.G.
        • Evans J.
        • et al.
        UK Guidelines for the management of cutaneous melanoma.
        Br J Plast Surg. 2002; 55: 46-54
        • Thompson J.F.
        • Saw R.P.
        • Colman M.H.
        • Howman-Giles R.B.
        • Uren R.F.
        Contralateral groin node metastasis from lower limb melanoma.
        Eur J Canc. 1997; 33: 976-977