Case Report| Volume 65, ISSUE 1, e9-e10, January 2012

Cicatricial ectropion: A complication of topical 5-fluorouracil

Published:August 29, 2011DOI:


      Topical 5-fluorouracil (5-FU) is a simple chemotherapeutic treatment that can be used by the plastic surgeon for indicated skin lesions. We present a case of transient, cicatricial ectropion developing secondarily to topical treatment with 5-FU, and propose an algorithm for the management of this significant complication.


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        • Straus D.J.
        • Mausolf F.A.
        • Ellerby R.A.
        • McCracken J.D.
        Cicatricial ectropion secondary to 5-fluorouracil therapy.
        Med Pediatr Oncol. 1977; 3: 15-19
        • Hurwitz B.S.
        Cicatricial ectropion: a complication of systemic fluorouracil.
        Arch Ophthalmol. 1993; 111: 1608-1609
        • Hecker D.
        • Hacker S.M.
        • Ramos-Caro F.A.
        • Flowers F.P.
        Temporary ectropion due to topical fluorouracil.
        Cutis. 1994; 53: 137-138
        • Galentine P.
        • Sloas H.
        • Hargett N.
        • Cupples H.P.
        Bilateral cicatricial ectropion following topical administration of 5-fluorouracil.
        Ann Ophthalmol. 1981; 13: 575-577