Summary
Autologous fat grafting is versatile tool in plastic surgery and is increasing used
for reconstruction following breast conserving surgery for breast cancer. Part of
the reconstructive qualities of the transferred fat may be due to the presence of
adipose derived mesenchymal stem cells (ADMSC) playing an angiogenic and an adipogenic
role.
In this context it must be considered if autologously engrafted fat tissue could contribute
to carcinogenesis following breast conserving surgery. In this article we review the
current stem cell biology evidence on engraftment, transdifferentiation and potential
carcinogenic contribution in the breast and other solid organ stem cell niches in
an attempt to highlight possible areas of concern.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Plastic, Reconstructive & Aesthetic SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Structural fat grafting: more than a permanent filler.Plast Reconstr Surg. 2006; 118: 108S-120S
- Facial recontouring with lipostructure.Clin Plast Surg. 1997; 24: 347-367
- Refinement of rhinoplasty with lipoinjection.Aesthet Plast Surg. 2007; 31: 501
- Rejuvenation of the periorbital complex with autologous fat transfer: current therapy.J Oral Maxillofac Surg. 2008; 66: 1686-1693
- Autologous fat transplantation.Plast Reconstr Surg. 1987; 79: 492-493
- Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells.Plast Reconstr Surg. 2007; 119: 1409-1422
- Cell-assisted lipotransfer for cosmetic breast augmentation: Supportive use of adipose derived stem/stromal cells.Aethet Plast Surg. 2008; 32: 48-55
- Hand rejuvenation with structural fat grafting.Plast Reconstr Surg. 2002; 110: 1731-1744
- Autologous fat transfer in reconstructive breast surgery: indications, technique and results.Eur J Surg Oncol. 2007; 33: 685-690
- Fat grafting to the breast revisited: safety and efficacy.Plast Reconstr Surg. 2007; 119: 775-785
- Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force.Plast Reconstr Surg. 2009; 124: 272-280
- Sonographic findings in complications of cosmetic breast augmentation with autologous fat obtained by liposuction.J Clin Ultrasound. 2004; 32: 299-301
- Radiological evaluation of breasts reconstructed with lipomodeling.Ann Chir Plast Esthet. 2006; 51: 18-28
- Long term clinical and radiologic results with autologous fat transplantation for breast augmentation: case reports and review of the literature.Breast J. 2006; 12: 63-65
- The science of autologous fat grafting: views on current and future approaches to neoadipogenesis.Aesthet Surg J. 2008; 28: 313-321
- Fat grafting to the breast and adipose-derived stem cells: recent scientific consensus and controversy.Aesthet Surg J. 2010; 30: 381-387
- Fat circadian biology.J Appl Physiol. 2009; 107: 1629-1637
- Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo.Acta Pharmacol Sin. 2006; 27: 1608-1615
- Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery.Plast Reconstr Surg. 2006; 118: 121S-128S
- Improvement of the survival of human autologous fat transplantation by using VEGF-transfected adipose-derived stem cells.Plast Reconstr Surg. 2009; 124: 1437-1446
- Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis.Clin Cancer Res. 2000; 6: 572-577
- Angiogenesis, adipokines and breast cancer.Cytokine Growth Factor Rev. 2001; 20: 193-201
- Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells.Oncogene. 2009; 28: 2745-2755
- Hematopoietic cell transplantation for Crohn’s disease; is it time?.World J Gastroenterol. 2006; 12: 6665-6673
- Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease.Gastroenterology. 2007; 132: 944-954
- A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.Gastroenterology. 2005; 128: 1984-1995
- Involvement of bone marrow-derived cells in healing of experimental colitis in rats.Wound Repair Regen. 2005; 13: 109-111
- Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts.Cancer Res. 2004; 64: 8492-8495
- Bone marrow-derived stromal cells express lineage-related messenger RNA species.Cancer Res. 2006; 66: 1265-1269
- Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.Cell. 2001; 105: 369-377
- Gastric cancer originating from bone marrow-derived cells.Science. 2004; 306: 1568-1571
- Human Barrett’s adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant.Stem Cells Dev. 2010; 20: 11-17
- Recipes for adult stem cell plasticity: fusion cuisine or readymade?.J Clin Pathol. 2004; 57: 113-120
- Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.Nature. 2002; 416: 542-545
- Changing potency by spontaneous fusion.Nature. 2002; 416: 545-598
- Contribution of bone marrow-derived endothelial cells to human tumor vasculature.Nat Med. 2005; 11: 261-262
- Putting tumours in context.Nat Rev Cancer. 2001; 1: 46-54
- The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer.Cancer Treat Res. 1991; 53: 93-106
- Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function.Cancer Res. 1995; 55: 2448-2454
- Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.Cancer Res. 2000; 60: 2562-2566
- Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.Cancer Res. 1999; 59: 5002-5011
- Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.Cancer Cell. 2011; 19: 257-272
- Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.Cancer Res. 2000; 60: 1254-1260
- Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast.Breast Cancer Res. 2003; 5: 130-135
- Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis.Int J Biochem Cell Biol. 2007; 39: 1987-1994
- Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions.J Pathol. 2003; 201: 221-228
- Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization.Oncogene. 2003; 22: 6408-6423
- Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo.Stem Cells Dev. 2008; 17: 463-473
- Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence.PLoS One. 2010; 5: e10999
- Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer.N Engl J Med. 1995; 333: 1456-1461
Article info
Publication history
Published online: August 05, 2011
Accepted:
July 9,
2011
Received:
May 23,
2011
Identification
Copyright
© 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Inc. All rights reserved.
