Advertisement

Tissue engineering with adipose-derived stem cells (ADSCs): Current and future applications

  • Aris Sterodimas
    Correspondence
    Corresponding author. Tel.: +55 2181843000.
    Affiliations
    Department of Plastic Surgery, Pontifical Catholic University of Rio de Janeiro and the Carlos Chagas Post-Graduate Medical Institute, Rua Dona Mariana 65, Zip: 22280-020, Rio de Janeiro, Brazil
    Search for articles by this author
  • Jose de Faria
    Affiliations
    Department of Plastic Surgery, Pontifical Catholic University of Rio de Janeiro and the Carlos Chagas Post-Graduate Medical Institute, Rua Dona Mariana 65, Zip: 22280-020, Rio de Janeiro, Brazil
    Search for articles by this author
  • Beatriz Nicaretta
    Affiliations
    Department of Plastic Surgery, Policlinca Geral, 38 Av Nilo Peçanha, Zip: 22020-100, Rio de Janeiro, Brazil
    Search for articles by this author
  • Ivo Pitanguy
    Affiliations
    Department of Plastic Surgery, Pontifical Catholic University of Rio de Janeiro and the Carlos Chagas Post-Graduate Medical Institute, Rua Dona Mariana 65, Zip: 22280-020, Rio de Janeiro, Brazil
    Search for articles by this author
Published:December 08, 2009DOI:https://doi.org/10.1016/j.bjps.2009.10.028

      Summary

      Soft-tissue loss presents an ongoing challenge in plastic and reconstructive surgery. Standard approaches to soft-tissue reconstruction include autologous tissue flaps, autologous fat transplantation and alloplastic implants. All of these approaches have disadvantages, including donor-site morbidity, implant migration and absorption and foreign body reaction. Stem cell application has recently been suggested as a possible novel therapy. Adipose-derived stem cells (ADSCs) are an abundant, readily available population of multipotent progenitor cells that reside in adipose tissue, which is an easily accessible and abundant source of putative stem cells for translational clinical research. Their therapeutic use in pre-clinical studies and experimental clinical trials has been well documented.
      We present the current strategies of tissue engineering with ADSC and we discuss the possible future applications of this new method in the field of plastic and reconstructive surgery. Complete understanding of the mechanisms of interactions among adipose stem cells, growth factors and biomaterials in tissue engineering is still lacking. Adipose tissue stem cell-based regenerative strategies hold tremendous promise, although this potential must be balanced against stringent standards of scientific and clinical investigation, before developing ‘off-the-shelf’ tissue engineering products.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Plastic, Reconstructive & Aesthetic Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Illouz Y.G.
        Adipoaspiration and "filling" in the face.
        Facial Plast Surg. 1992 Jan; 8 ([No abstract available]): 59-71
        • Sterodimas A.
        • Huanquipaco J.C.
        • de Souza Filho S.
        • et al.
        Autologous fat transplantation for the treatment of Parry-Romberg syndrome.
        J Plast Reconstr Aesthet Surg. 2008 Aug 15; ([Epub ahead of print])
        • Kaufman M.R.
        • Miller T.A.
        • Huang C.
        • et al.
        Autologous fat transfer for facial recontouring: is there science behind the art?.
        PlastReconstr Surg. 2007 Jun; 119: 2287
        • Thomson J.A.
        • Itskovitz-Eldor J.
        • Shapiro S.S.
        • et al.
        Embryonic stem cell lines derived from human blastocysts.
        Science. 1998 Nov 6; 282: 1145-1147
        • Jiang Y.
        • Jahagirdar B.N.
        • Reinhardt R.L.
        • et al.
        Pluripotency of mesenchymal stem cells derived from adult marrow.
        Nature. 2002 Jul 4; 418 (Epub 2002 Jun 20): 41-49
        • Sterodimas A.
        • De Faria J.
        • Correa W.E.
        • et al.
        Tissue engineering in plastic surgery: an up-to-date review of the current literature.
        Ann Plast Surg. 2009 Jan; 62 (Review): 97-103
        • Rodbell M.
        Localization of lipoprotein lipase in fat cells of rat adipose tissue.
        J Biol Chem. 1964 Mar; 239: 753-755
        • Van R.L.
        • Roncari D.A.
        Isolation of fat cell precursors from adult rat adipose tissue.
        Cell Tissue Res. 1977 Jul 11; 181: 197-203
        • Illouz Y.G.
        Body contouring by lipolysis: a 5-year experience with over 3000 cases.
        Plast Reconstr Surg. 1983 Nov; 72: 591-597
        • Zuk P.A.
        • Zhu M.
        • Mizuno H.
        • et al.
        Multilineage cells from human adipose tissue: implications for cell-based therapies.
        Tissue Eng. 2001; 7: 211-226
        • Liu Z.J.
        • Zhuge Y.
        • Velazquez O.C.
        Trafficking and differentiation of mesenchymal stem cells.
        J Cell Biochem. 2009 Feb 19; ([Epub ahead of print])
        • Zocchi M.L.
        Zuliani F.Bicompartmental breast lipostructuring.
        Aesthetic Plast Surg. 2008 Mar; 32: 313-328
        • Ogawa R.
        The importance of adipose-derived stem cells and vascularized tissue regeneration in the field of tissue transplantation.
        Curr Stem Cell Res Ther. 2006 Jan; 1 (Review): 13-20
        • Rubin J.P.
        • Bennett J.M.
        • Doctor J.S.
        • et al.
        Plast Reconstr Surg. 2007 Aug; 120: 414-424
        • Condé-Green A.
        • Gontijo de Amorim N.F.
        • Pitanguy I.
        Influence of decantation, washing and centrifugation on adipocyte and mesenchymal stem cell content of aspirated adipose tissue: a comparative study.
        J Plast Reconstr Aesthet Surg. 2009 Aug 11; ([Epub ahead of print])
        • Schipper B.M.
        • Marra K.G.
        • Zhang W.
        • et al.
        Regional anatomic and age effects on cell function of human adipose-derived stem cells.
        Ann Plast Surg. 2008 May; 60: 538-544
        • Jurgens W.J.
        • Oedayrajsingh-Varma M.J.
        • Helder M.N.
        • et al.
        Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies.
        Cell Tissue Res. 2008 Jun; 332 (Epub 2008 Apr 1): 415-426
        • Gonda K.
        • Shigeura T.
        • Sato T.
        • et al.
        Preserved proliferative capacity and multipotency of human adipose-derived stem cells after long-term cryopreservation.
        Plast Reconstr Surg. 2008 Feb; 121: 401-410
        • De Rosa A.
        • De Francesco F.
        • Tirino V.
        • et al.
        A new method for the cryopreserving ASCs: an attractive and suitable large-scale and long-term cell banking technology.
        Tissue Eng Part C Methods. 2009 Mar 2; ([Epub ahead of print])
        • Estes B.T.
        • Diekman B.O.
        • Guilak F.
        Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells.
        Biotechnol Bioeng. 2008 Mar 1; 99: 986-995
        • Parker A.M.
        • Shang H.
        • Khurgel M.
        • et al.
        Low serum and serum-free culture of multipotential human adipose stem cells.
        Cytotherapy. 2007; 9: 637-646
        • Kakudo N.
        • Minakata T.
        • Mitsui T.
        • et al.
        Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts.
        Plast Reconstr Surg. 2008 Nov; 122: 1352-1360
        • Lund P.
        • Pilgaard L.
        • Duroux M.
        • et al.
        Effect of growth media and serum replacements on the proliferation and differentiation of adipose-derived stem cells.
        Cytotherapy. 2009 Feb 25; ([Epub ahead of print]): 1-9
        • Kurita M.
        • Aiba-Kojima E.
        • Shigeura T.
        • et al.
        Differential effects of three preparations of human serum on expansion of various types of human cells.
        Plast Reconstr Surg. 2008 Aug; 122: 438-448
        • Lu F.
        • Gao J.H.
        • Ogawa R.
        • et al.
        Adipose tissues differentiated by adipose-derived stem cells harvested from transgenic mice.
        Chin J. Traumatol. 2006 Dec; 9: 359-364
        • Zhang Y.S.
        • Gao J.H.
        • Lu F.
        • et al.
        [Cellular compatibility of type collagen I scaffold and human adipose-derived stem cells].
        Nan Fang Yi Ke Da Xue Xue Bao. 2007 Feb; 27: 223-225
        • Stillaert F.B.
        • Di Bartolo C.
        • Hunt J.A.
        • et al.
        Human clinical experience with adipose precursor cells seeded on hyaluronic acid-based spongy scaffolds.
        Biomaterials. 2008 Oct; 29 (Epub 2008 Jul 17): 3953-3959
        • Itoi Y.
        • Takatori M.
        • Hyakusoku H.
        • et al.
        Comparison of readily available scaffolds for adipose tissue engineering using adipose-derived stem cells.
        J Plast Reconstr Aesthet Surg. 2009 Apr 13; ([Epub ahead of print])
        • Flynn L.E.
        • Prestwich G.D.
        • Semple J.L.
        • et al.
        Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells.
        Biomaterials. 2007 Sep; 28 ([Epub 2007 May 16]): 3834-3842
        • Flynn L.E.
        • Prestwich G.D.
        • Semple J.L.
        • et al.
        Proliferation and differentiation of adipose-derived stem cells on naturally derived scaffolds.
        Biomaterials. 2008 Apr; 29 ([Epub 2008 Feb 1]): 1862-1871
        • Choi Y.S.
        • Cha S.M.
        • Lee Y.Y.
        • et al.
        Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse.
        Biochem Biophys Res Commun. 2006 Jun 30; 345 ([Epub 2006 May 2]): 631-637
        • Altman A.M.
        • Yan Y.
        • Matthias N.
        • et al.
        IFATS Series: human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model.
        Stem Cells. 2008 Sep 25; ([Epub ahead of print])
        • Hemmrich K.
        • von Heimburg D.
        Expert Rev Med Devices. 2006 Sep; 3 (Review): 635-645
        • Kakudo N.
        • Shimotsuma A.
        Kusumoto K.Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells.
        Biochem Biophys Res Coommun. 2007 Jul 27; 359 ([Epub 2007 May 21.]): 239-244
        • Suga H.
        • Eto H.
        • Shigeura T.
        • et al.
        Yoshimura K.IFATS Series: FGF-2-induced HGF Secretion By Adipose-Derived Stromal Cells Inhibits Post-Injury Fibrogenesis Through A JNK-Dependent Mechanism.
        Stem Cells. 2008 Sep 4; ([Epub ahead of print])
        • Prichard H.L.
        • Reichert W.
        • Klitzman B.
        IFATS collection: adipose-derived stromal cells improve the foreign body response.
        Stem Cells. 2008 Oct; 26 ([Epub 2008 Apr 24]): 2691-2695
        • Yoshimura K.
        • Sato K.
        • Aoi N.
        • et al.
        Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells.
        Aesthetic Plast Surg. 2008 Jan; 32 (discussion 56-7. Epub 2007 Sep 1): 48-55
      1. Pereira LH, Sterodimas A Free fat transplantation for the aesthetic correction of mild pectus excavatum. Aesth Plast Surg 32:393–396

        • Haroldo Pereira L.
        Sterodimas a aesthetic restoration of axillary contour deformity after lymph node dissection.
        J Plast Reconstr Aesthet Surg. 2007 Nov 19; 61 (Epub): 231-232
        • Pereira L.H.
        • Sterodimas A.
        Long-term fate of transplanted autologous fat in the face.
        J Plast Reconstr Aesthet Surg. 2009 Mar 10; ([Epub ahead of print])
        • Santana K.P.
        • Pereira L.H.
        • Sabatovich O.
        • et al.
        Foreign-body granulomas caused by polymethylmethacrylate (PMMA) microspheres: successful correction by autologous fat transplantation.
        J Plast Reconstr Aesthet Surg. 2009 Apr 1; ([Epub ahead of print])
        • Pereira L.H.
        • Sterodimas A.
        Macroscopic and microscopic proof of long-term survival of gluteal fat transplantation.
        Plast Reconstr Surg. 2009 Apr; 123: 162e-163e
        • Pereira L.H.
        • Sterodimas A.
        Autologous Fat Transplantation and Delayed Silicone Implant insertion in a case of mycobacterium avium breast infection.
        Aesthetic Plast Surg. 2009 Jun 4; ([Epub ahead of print])
        • Illouz Y.G.
        Sterodimas A Autologous Fat Transplantation to the Breast: A Personal Technique with 25 Years of Experience.
        Aesthetic Plast Surg. 2009 Jun 4; ([Epub ahead of print])
        • Matsumoto D.
        • Sato K.
        • Gonda K.
        • et al.
        Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection.
        Tissue Eng. 2006 Dec; 12: 3375-3382
        • Yoshimura K.
        • Sato K.
        • Aoi N.
        • et al.
        Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells.
        Dermatol Surg. 2008 Sep; 34 ([Epub 2008 May 29]): 1178-1185
        • Rigotti G.
        • Marchi A.
        • Galiè M.
        • et al.
        Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells.
        Plast Reconstr Surg. 2007 Apr 15; 119 (1409-22; discussion): 1423-1424
        • Moseley T.A.
        • Zhu M.
        • Hedrick M.H.
        Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery.
        Plast Reconstr Surg. 2006 Sep; 118 ([121S-128S. Review.])
        • Stillaert F.B.
        • Di Bartolo C.
        • Hunt J.A.
        • et al.
        Human clinical experience with adipose precursor cells seeded on hyaluronic acid-based spongy scaffolds.
        Biomaterials. 2008 Oct; 29 ([Epub 2008 Jul 17]): 3953-3959
        • Lu F.
        • Mizuno H.
        • Uysal C.A.
        • et al.
        Improved viability of random pattern skin flaps through the use of adipose-derived stem cells.
        Plast Reconstr Surg. 2008 Jan; 121: 50-58
        • Mesimäki K.
        • Lindroos B.
        • Törnwall J.
        • et al.
        Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells.
        Int J Oral Maxillofac Surg. 2009 Mar; 38 ([Epub 2009 Jan 24]): 201-209