Introduction: Dupuytren's disease is a common fibrocontractile disorder affecting the palmar fascia of the hand that can cause severe disability. Despite advances in surgical management, recurrence remains a common complication. The matrix metalloproteases (MMPs) are a large family of proteolytic enzymes that play an integral role in scarring in vivo and collagen contraction in vitro. The purpose of this study was to assess the influence of MMP on matrix contraction by Dupuytren's fibroblasts using the broad-spectrum MMP inhibitor, ilomastat.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Plastic, Reconstructive & Aesthetic Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
© 2007 Published by Elsevier Inc.