Abstract| Volume 60, ISSUE 4, PS9, April 2007

The influence of mmp activity on force generation by dupuytren's fibroblasts

      Introduction: Dupuytren's disease is a common fibrocontractile disorder affecting the palmar fascia of the hand that can cause severe disability. Despite advances in surgical management, recurrence remains a common complication. The matrix metalloproteases (MMPs) are a large family of proteolytic enzymes that play an integral role in scarring in vivo and collagen contraction in vitro. The purpose of this study was to assess the influence of MMP on matrix contraction by Dupuytren's fibroblasts using the broad-spectrum MMP inhibitor, ilomastat.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Plastic, Reconstructive & Aesthetic Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect