Introduction: Dupuytren's disease is a common fibrocontractile disorder affecting the palmar fascia
of the hand that can cause severe disability. Despite advances in surgical management,
recurrence remains a common complication. The matrix metalloproteases (MMPs) are a
large family of proteolytic enzymes that play an integral role in scarring in vivo
and collagen contraction in vitro. The purpose of this study was to assess the influence
of MMP on matrix contraction by Dupuytren's fibroblasts using the broad-spectrum MMP
inhibitor, ilomastat.
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© 2007 Published by Elsevier Inc.
