Abstract| Volume 60, ISSUE 4, PS9, April 2007

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VEGF165 transfection of ex vivo expanded keratinocytes promotes healing and neovascularization in porcine full thickness skin wounds

      Background: A trigger to enhance Full Thickness Wound (FTW) repair is delivery of oxygen and nutritients to the wound site. After the initial inflammatory phase, platelets and keratinocytes (KC) start to secrete Vascular Endothelial Growth Factor (VEGF) to attract Endothelial Cells into the wound granulation tissue. We present a method of ex vivo expansion of autologous KC and lipid mediated gene transfer of a regulable VEGF165 plasmid for the treatment of FTW.
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