Introduction and Aims: Melanoma is resistant to standard chemotherapies and few therapeutic measures improve patient survival in the metastatic stage of the disease. CYP1B1, a member of the cytochrome P450 enzyme family, appears to be over-expressed in a number of human malignancies whilst exhibiting little protein expression in normal tissues. CYP1B1 protein expression was investigated in primary and metastatic melanoma to assess its potential as a target for pro-drug therapy.
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© 2007 Published by Elsevier Inc.