The aim of this study was to investigate the effect of a highly viscous, left-shifted
hemoglobin vesicle solution (HbV) on the hypoxia-related inflammation and the microcirculation
in critically ischemic peripheral tissue. Island flaps were dissected from the back
skin of anesthetized hamsters for assessment with intravital microscopy. The flap
included a critically ischemic, hypoxic area that was perfused via a collateralized
vasculature. One hour after completion of the preparation, the animals received an
injection of 25% of total blood volume of 0.9%NaCl (n=6), or NaCl suspended with HbVs at a concentration of 5 g/dl (HbV5, n=6) or 10 g/dl (HbV10, n=6). The experiments were approved by the local Animal Ethics Committee.
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© 2007 Published by Elsevier Inc.
