Abstract| Volume 60, ISSUE 4, PS6-S7, April 2007

Aging is associated with an increased susceptibility for ischemic tissue necrosis due to microvascular perfusion failure rather than reduction of ischemic tolerance

      Introduction: Lately, following surgery, aging has been associated with a higher incidence for ischemic tissue complications and organ dysfunction, a fact not imperatively related to a higher number of comorbidities. We therefore analyzed in a murine model of chronic ischemia whether (i) aging is associated with an increased susceptibility for ischemic necrosis, and whether (ii) this is based on microvascular dysfunction or reduced ischemic tolerance.
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