Introduction: Lately, following surgery, aging has been associated with a higher incidence for
ischemic tissue complications and organ dysfunction, a fact not imperatively related
to a higher number of comorbidities. We therefore analyzed in a murine model of chronic
ischemia whether (i) aging is associated with an increased susceptibility for ischemic
necrosis, and whether (ii) this is based on microvascular dysfunction or reduced ischemic
tolerance.
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© 2007 Published by Elsevier Inc.
