Introduction: Reconstruction of peripheral nerve lesions remains a major challenge in plastic
surgery. Clinical strategies to treat extensive peripheral nerve injuries include
the use of nerve. The goal of the current study is the development of a bioartificially
synthesized nerve graft. We present modifications of a specially designed collagen
matrix with the attempt to achieve the standard of autologous nerve grafts. The objective
is to advance previous in-vivo regeneration results by improving the schwann cell-biomaterial
interaction.
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© 2007 Published by Elsevier Inc.
