Abstract| Volume 60, ISSUE 4, PS3-S4, April 2007

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RGTA, a synthetic glycosaminoglycan mimetic, significantly reduces neural adhesions after peripheral nerve injury in rats

      Aims: Extra- and intraneural scar formation after peripheral nerve injury frequently causes tethering and compression of the nerve as well as inhibition of axonal regeneration. ReGeneraTing Agents (RGTAs) mimic the stabilizing and protective properties of sulphated glycosaminoglycan (GAG) towards heparin-binding growth factors (HBGFs). The aim of this study was to assess the effect of a RGTA, named OTR4120, on extraneural fibrosis and axonal regeneration after crush injury in a rat sciatic nerve model.
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