RGTA, a synthetic glycosaminoglycan mimetic, significantly reduces neural adhesions after peripheral nerve injury in rats

H.M. Zuijdendorp; X. Smit; B.S. de Kool; J.H. Blok; J.P. Caruelle; D. Barritault; S.E.R. Hovius; J.W. van Neck

doi:10.1016/j.bjps.2007.01.018

Abstract| Volume 60, ISSUE 4, PS3-S4, April 2007

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RGTA, a synthetic glycosaminoglycan mimetic, significantly reduces neural adhesions after peripheral nerve injury in rats

H.M. Zuijdendorp
H.M. Zuijdendorp
Affiliations
Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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X. Smit
X. Smit
Affiliations
Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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B.S. de Kool
B.S. de Kool
Affiliations
Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Clinical Neurophysiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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J.H. Blok
J.H. Blok
Affiliations
Department of Clinical Neurophysiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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J.P. Caruelle
J.P. Caruelle
Affiliations
Lab CRRET, Université Paris XII-Val de Marne, Créteil, France
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D. Barritault
D. Barritault
Affiliations
OTR3 Laboratories, 4 rue Francaise 75001 Paris, France
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S.E.R. Hovius
S.E.R. Hovius
Affiliations
Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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J.W. van Neck
J.W. van Neck
Affiliations
Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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DOI:https://doi.org/10.1016/j.bjps.2007.01.018

Aims: Extra- and intraneural scar formation after peripheral nerve injury frequently causes tethering and compression of the nerve as well as inhibition of axonal regeneration. ReGeneraTing Agents (RGTAs) mimic the stabilizing and protective properties of sulphated glycosaminoglycan (GAG) towards heparin-binding growth factors (HBGFs). The aim of this study was to assess the effect of a RGTA, named OTR4120, on extraneural fibrosis and axonal regeneration after crush injury in a rat sciatic nerve model.

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DOI: https://doi.org/10.1016/j.bjps.2007.01.018

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RGTA, a synthetic glycosaminoglycan mimetic, significantly reduces neural adhesions after peripheral nerve injury in rats

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