Summary
Radiation-impaired wounds are characterized by fibroblast and endothelial cell injury,
resulting in delayed wound healing. Several previous studies have indicated that chitosan
accelerates wound healing by up-regulating growth factor synthesis. In this study,
the topical application of chitosan onto radiation-impaired wounds was investigated.
An X-ray irradiated (25 Gy) skin wound was treated with cotton fibre-type chitosan in dogs. Histopathologically,
neovascularization was significantly accelerated in irradiated wounds in the chitosan
application group (rad–chi group) when compared with irradiated wounds in the control
group (rad–cont group). Vascular endothelial growth factor (VEGF) messenger ribonucleic
acid (mRNA) expression in granulation tissue was positive in the rad–chi group, but
was negative in the rad–cont group. The present results confirmed advanced granulation
and capillary formation in wounds treated with chitosan, even after irradiation.
Keywords
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Article info
Publication history
Published online: September 20, 2006
Accepted:
June 7,
2006
Received:
March 7,
2006
Footnotes
☆This work was presented at the Organizing Committee of 6th International Conference of the European Chitin Society (Poznan, Poland from August 31 to September 3, 2004).
Identification
Copyright
© 2006 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Inc. All rights reserved.
