Case report| Volume 60, ISSUE 11, P1252-1255, November 2007

Download started.


Malignant melanoma and deep penetrating naevus – difficulties in diagnosis in children


      A 4-year-old boy presented to our department with a darkly pigmented lesion on the right side of his neck. It was excised and a diagnosis of deep penetrating naevus with atypical features was made. At 4-month follow-up our patient had developed a palpable cervical lymph node. Excision revealed malignant melanoma. We discuss our management and review the literature regarding DPN and melanoma of childhood.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Plastic, Reconstructive & Aesthetic Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Ceballos P.
        • Ruiz-Maldonado R.
        • Mihm M.C.
        Melanoma in children.
        N Engl J Med. 1995; 332: 656-662
        • Saenz N.C.
        • Saenz-Badillos J.
        • Busam K.
        • et al.
        Childhood melanoma survival.
        Cancer. 1999; 85: 750-754
        • Seab Jr., J.A.
        • Graham J.H.
        • Helwig E.B.
        Deep penetrating naevus.
        Am J Surg Pathol. 1989; 13: 39-44
        • Cooper P.H.
        Deep penetrating (plexiform spindle cell) naevus. A frequent participant in combined naevus.
        J Cutan Pathol. 1992; 19: 172-180
        • Mehregan D.A.
        • Mehregan A.H.
        Deep penetrating naevus.
        Arch Dermatol. 1993; 129: 328-331
        • Mehregan D.R.
        • Mehregan D.A.
        • Mehregan A.H.
        Proliferating cell nuclear antigen staining in deep-penetrating naevi.
        J Am Acad Dermatol. 1995; 33: 685-687
        • Robson A.
        • Morley-Quante M.
        • Hempel H.
        • et al.
        Deep penetrating naevus: clinicopathological study of 31 cases with further delineation of histological features allowing distinction from other pigmented benign melanocytic lesions and melanoma.
        Histopathology. 2003; 43: 529-537
        • Zembowicz A.
        • Carney J.A.
        • Mihm M.C.
        Pigmented epithelioid melanocytoma: a low-grade tumour with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus.
        Am J Surg Pathol. 2004; 28: 31-40
        • Ferrari A.
        • Bono A.
        • Baldi M.
        • et al.
        Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution.
        Pediatrics. 2005 Mar; 115: 649-654
        • Edwards S.L.
        • Blessing K.
        Problematic pigmented lesions: approach to diagnosis.
        J Clin Pathol. 2000; 53: 409-418
        • Pappo A.S.
        Melanoma in children and adolescents.
        Eur J Cancer. 2003; 39: 2651-2661
        • Barnhill R.L.
        • Flotte T.J.
        • Fleischli M.
        • et al.
        Cutaneous melanoma and atypical Spitz tumors in childhood.
        Cancer. 1995; 76: 1833-1845
        • Urso C.
        • Rongioletti F.
        • Innocenzi D.
        • et al.
        Histological features used in the diagnosis of melanoma are frequently found in benign melanocytic naevi.
        J Clin Pathol. 2005; 58: 409-412