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Case report| Volume 60, ISSUE 11, P1252-1255, November 2007

Malignant melanoma and deep penetrating naevus – difficulties in diagnosis in children

      Summary

      A 4-year-old boy presented to our department with a darkly pigmented lesion on the right side of his neck. It was excised and a diagnosis of deep penetrating naevus with atypical features was made. At 4-month follow-up our patient had developed a palpable cervical lymph node. Excision revealed malignant melanoma. We discuss our management and review the literature regarding DPN and melanoma of childhood.

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      References

        • Ceballos P.
        • Ruiz-Maldonado R.
        • Mihm M.C.
        Melanoma in children.
        N Engl J Med. 1995; 332: 656-662
        • Saenz N.C.
        • Saenz-Badillos J.
        • Busam K.
        • et al.
        Childhood melanoma survival.
        Cancer. 1999; 85: 750-754
        • Seab Jr., J.A.
        • Graham J.H.
        • Helwig E.B.
        Deep penetrating naevus.
        Am J Surg Pathol. 1989; 13: 39-44
        • Cooper P.H.
        Deep penetrating (plexiform spindle cell) naevus. A frequent participant in combined naevus.
        J Cutan Pathol. 1992; 19: 172-180
        • Mehregan D.A.
        • Mehregan A.H.
        Deep penetrating naevus.
        Arch Dermatol. 1993; 129: 328-331
        • Mehregan D.R.
        • Mehregan D.A.
        • Mehregan A.H.
        Proliferating cell nuclear antigen staining in deep-penetrating naevi.
        J Am Acad Dermatol. 1995; 33: 685-687
        • Robson A.
        • Morley-Quante M.
        • Hempel H.
        • et al.
        Deep penetrating naevus: clinicopathological study of 31 cases with further delineation of histological features allowing distinction from other pigmented benign melanocytic lesions and melanoma.
        Histopathology. 2003; 43: 529-537
        • Zembowicz A.
        • Carney J.A.
        • Mihm M.C.
        Pigmented epithelioid melanocytoma: a low-grade tumour with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus.
        Am J Surg Pathol. 2004; 28: 31-40
        • Ferrari A.
        • Bono A.
        • Baldi M.
        • et al.
        Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution.
        Pediatrics. 2005 Mar; 115: 649-654
        • Edwards S.L.
        • Blessing K.
        Problematic pigmented lesions: approach to diagnosis.
        J Clin Pathol. 2000; 53: 409-418
        • Pappo A.S.
        Melanoma in children and adolescents.
        Eur J Cancer. 2003; 39: 2651-2661
        • Barnhill R.L.
        • Flotte T.J.
        • Fleischli M.
        • et al.
        Cutaneous melanoma and atypical Spitz tumors in childhood.
        Cancer. 1995; 76: 1833-1845
        • Urso C.
        • Rongioletti F.
        • Innocenzi D.
        • et al.
        Histological features used in the diagnosis of melanoma are frequently found in benign melanocytic naevi.
        J Clin Pathol. 2005; 58: 409-412