Recent advances in molecular researches on wound healing indicate that topical application of growth factors such as platelet derived growth factor (PDGF) or basic fibroblast growth factor (bFGF) is a promising approach for treating chronic ulcers.
1Especially in Japan, recombinant human bFGF was already approved and is now commercially available (Fiblast® by Kaken Pharmaceutical, Tokyo, Japan) and widely used throughout the country for treatment of chronic and pressure ulcers with considerable effectiveness.
- Schultz G.S.
- Sibbald R.G.
- Falanga V.
- et al.
Wound bed preparation: a systematic approach to wound management.
Wound Repair Regen. 2003; 11: S1-S28
- Aragane Y.
- Okamoto T.
- Yajima A.
- et al.
Hydroxyurea-induced foot ulcer successfully treated with a topical basic fibroblast growth factor product.
Br J Dermatol. 2003; 148: 599-600
3bFGF, a representative of FGF families, promotes wound healing by inducing angiogenesis and stimulating cellular proliferation in the wounds.
- Kurokawa I.
- Hayami J.
- Kita Y.
A therapy-resistant chronic leg ulcer treated successfully with topical basic fibroblast growth factor.
J Int Med Res. 2003; 31: 149-151
4However, biological effects of most growth factors are never specific to wound healing, implying that administration of growth factors for wound healing might result in unexpected adverse reactions. We herein report two cases with heterotopic ossification within sacral pressure ulcers treated with bFGF.
- Werner S.
- Grose R.
Regulation of wound healing by growth factors and cytokines.
Physiol Rev. 2003; 83: 835-870
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- Wound bed preparation: a systematic approach to wound management.Wound Repair Regen. 2003; 11: S1-S28
- Hydroxyurea-induced foot ulcer successfully treated with a topical basic fibroblast growth factor product.Br J Dermatol. 2003; 148: 599-600
- A therapy-resistant chronic leg ulcer treated successfully with topical basic fibroblast growth factor.J Int Med Res. 2003; 31: 149-151
- Regulation of wound healing by growth factors and cytokines.Physiol Rev. 2003; 83: 835-870
- Heterotopic ossification.J Nucl Med. 2002; 43: 346-353
- Mutations in fibroblast growth factor receptor 2 gene and craniosynostotic syndromes in Japanese children.J Craniofac Surg. 1998; 9: 162-170
- Osteoinductive molecules in orthopaedics: basic science and preclinical studies.Clin Orthop. 2002; : 33-43
- Novel method to enhance sternal healing after harvesting bilateral internal thoracic arteries with use of basic fibroblast growth factor.Circulation. 2000; 102 (III307–III11)
Published online: June 15, 2006
☆This work was presented in part at the 47th Annual Meeting of Japan Society of Plastic and Reconstructive Surgery, held in Tokyo, Japan on 9 April 2004, and at the 6th Annual Meeting of Japanese Society of Pressure Ulcers, held in Sapporo, Japan on 3 September 2004.
© 2006 The British Association of Plastic Surgeons. Published by Elsevier Inc. All rights reserved.