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Case report| Volume 60, ISSUE 8, P952-954, August 2007

The role of sentinel node biopsy in the management of melanocytic lesions of uncertain malignant potential (MUMP)

  • G.J. McArthur
    Correspondence
    Corresponding author. Tel.: +44 20 8725 1628; fax: +44 20 8725 2416.
    Affiliations
    Department of Plastic and Reconstructive Surgery, St. George's Hospital NHS Trust, Blackshaw Road, Tooting London SW17 0QT, United Kingdom
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  • M.E. Banwell
    Affiliations
    Department of Plastic and Reconstructive Surgery, St. George's Hospital NHS Trust, Blackshaw Road, Tooting London SW17 0QT, United Kingdom
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  • Author Footnotes
    1 Tel.: +44 1483 464065; fax: +44 1483 452718.
    M.G. Cook
    Footnotes
    1 Tel.: +44 1483 464065; fax: +44 1483 452718.
    Affiliations
    Department of Plastic and Reconstructive Surgery, St. George's Hospital NHS Trust, Blackshaw Road, Tooting London SW17 0QT, United Kingdom

    Department of Histopathology, Royal Surrey County Hospital, Egerton Road, Guildford, GU2 7XX, United Kingdom
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  • B.W. Powell
    Affiliations
    Department of Plastic and Reconstructive Surgery, St. George's Hospital NHS Trust, Blackshaw Road, Tooting London SW17 0QT, United Kingdom
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  • Author Footnotes
    1 Tel.: +44 1483 464065; fax: +44 1483 452718.

      Summary

      Melanocytic lesions of uncertain malignant potential (MUMP) is a term which is useful in identifying melanocytic tumours where the distinction between benign and malignant is a histological problem. Sentinel node biopsy is recognised to provide unmatched prognostic information in melanoma patients, but has recently been advocated for diagnostic purposes in MUMP.
      We present the case of a seven-year-old girl who presented with a six-month history of a changing pigmented lesion on her left upper arm. Excision biopsy not only showed a melanocytic lesion with some spitzoid features but also marked atypia making it appropriate to use the term MUMP. Sentinel node biopsy was undertaken.
      This case demonstrates that sentinel node biopsy can be performed safely in children. Given the low morbidity of the procedure we advocate that this technique should be considered in this difficult diagnostic situation to further the management of these patients.

      Keywords

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      References

        • Brady M.S.
        • Weinberg H.
        • Kraus D.
        • et al.
        Lymphatic mapping in the management of melanoma in children.
        Pediatr Dermatol. 1998; 15: 421-425
        • Roaten J.B.
        • Partrick D.A.
        • Bensard D.
        • et al.
        Survival in sentinel lymph node-positive pediatric melanoma.
        J Pediatr Surg. 2005; 40: 988-992
        • Durrani A.J.
        • Moir G.C.
        • Diaz-Cano S.J.
        • et al.
        Malignant melanoma in an 8-year-old Caribbean girl: diagnostic criteria and utility of sentinel lymph node biopsy.
        Br J Dermatol. 2003; 148: 569-572
        • Neville H.L.
        • Andrassy R.J.
        • Lally K.P.
        • et al.
        Lymphatic mapping with sentinel node biopsy in pediatric patients.
        J Pediatr Surg. 2000; 35: 961-964
        • Kelley S.W.
        • Cockerell C.J.
        Sentinel lymph node biopsy as an adjunct to management of histologically difficult to diagnose melanocytic lesions: a proposal.
        Acad Dermatol. 2000; 42: 527-530