Autologous fat transplantation for filling defects or augmenting tissue is a common procedure but may have unreliable results. While fibrin glues lead to increased proliferation of fibroblasts and local accumulation of vascular endothelial growth factor, which enhances the neovascularisation, in this study the efficacy of fibrin glues on fat graft survival was investigated. Inguinal fat pads from Sprague–Dawley rats were harvested and same volumes of autogenous fat grafts were implanted into the separate pockets with the aid of fibrin glue (Group 1) and saline solution (Group 2). All the fat grafts were harvested, washed, blotted dry, and volumetrically measured with the same method used peroperatively at 6 months after implantation. Mean graft survival values for Group 1 were compared with Group 2 and histopathological evaluation of the grafts was also made. There was a significantly higher survival rate of the grafts in Group 1 than control group (79±4% and 55±6%, respectively). Histopathological examination of the grafts demonstrated evident increase in neovascularisation of the fat grafts in the experimental group. The authors conclude that the fibrin glue significantly diminishes the fat graft resorption and further well-controlled studies are required before using fibrin glues for clinical purposes.
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- Present results of fat injection.Aesthetic Plast Surg. 1988; 12: 175-181
- Transplantation of purified autologous fat: a 3-year follow-up is disappointing.Plast Reconstr Surg. 1991; 87: 219-227
- Bioactivation of free-fat transfers: a potential new approach to improving graft survival.Plast Reconstr Surg. 1992; 90: 1022-1030
- Enhancing the survival of aspirated human fat injected into nude mice.Plast Reconstr Surg. 1998; 101: 1940-1944
- Comparative study of survival of autologous adipose tissue taken and transplanted by different techniques.Plast Reconstr Surg. 1990; 85: 378-386
- Experimental and clinical applications of fibrin glue.Plast Reconstr Surg. 1991; 88: 1005-1015
- Fibrin seal: the state of the art.J Oral Maxillofac Surg. 1985; 43: 605-611
- Biological in vitro effects of fibrin glue: fibroblast proliferation, expression and binding of growth factors.Scand J Gastroenterol. 2004; 39: 927-932
- Unproven treatment: whose benefit, whose responsibility?.Plast Reconstr Surg. 1988; 81: 946-947
- Long-term results of fat transplantation: clinical and histologic studies.Plast Reconstr Surg. 1994; 94: 496-506
- Enhancing the take of injected adipose tissue by a simple method for concentrating fat cells.Plast Reconstr Surg. 2005; 115: 197-201
- Increased free fat-graft survival with the long-term, local delivery of insulin, insulin-like growth factor-I, and basic fibroblast growth factor by PLGA/PEG microspheres.Plast Reconstr Surg. 2000; 105: 1712-1720
- Free autogenous pearl fat grafts in the face – a preliminary report of a rediscovered technique.Ann Plast Surg. 1986; 16: 179-194
- Fat autograft: experimental study.in: Hinderer U.T. Plastic surgery. vol. II. Elsevier, Amsterdam1992
- Histopathologic evaluation of adipose autografts in a rabbit ear model.Otolaryngol Head Neck Surg. 1990; 102: 314-321
- Mechanical properties of fibrinogen adhesive material.in: Winter G.D. Gibbons G.F. Plenk H. Biomaterials. Wiley, London1980
- Growth regulation of fibroblasts by thrombin, factor XIII and fibronectin.Klin Wochenschr. 1981; 59: 145-146
- Warning: fatal reaction to the use of fibrin glue in deep hepatic wounds. Case reports.J Trauma. 1991; 31: 408-411
Published online: June 09, 2006
Accepted: March 4, 2006
Received: December 21, 2005
© 2006 The British Association of Plastic Surgeons. Published by Elsevier Inc. All rights reserved.