Summary
Autologous fat transplantation for filling defects or augmenting tissue is a common
procedure but may have unreliable results. While fibrin glues lead to increased proliferation
of fibroblasts and local accumulation of vascular endothelial growth factor, which
enhances the neovascularisation, in this study the efficacy of fibrin glues on fat
graft survival was investigated. Inguinal fat pads from Sprague–Dawley rats were harvested
and same volumes of autogenous fat grafts were implanted into the separate pockets
with the aid of fibrin glue (Group 1) and saline solution (Group 2). All the fat grafts
were harvested, washed, blotted dry, and volumetrically measured with the same method
used peroperatively at 6 months after implantation. Mean graft survival values for
Group 1 were compared with Group 2 and histopathological evaluation of the grafts
was also made. There was a significantly higher survival rate of the grafts in Group
1 than control group (79±4% and 55±6%, respectively). Histopathological examination of the grafts demonstrated evident
increase in neovascularisation of the fat grafts in the experimental group. The authors
conclude that the fibrin glue significantly diminishes the fat graft resorption and
further well-controlled studies are required before using fibrin glues for clinical
purposes.
Keywords
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Article info
Publication history
Published online: June 09, 2006
Accepted:
March 4,
2006
Received:
December 21,
2005
Identification
Copyright
© 2006 The British Association of Plastic Surgeons. Published by Elsevier Inc. All rights reserved.
