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Abstract
Isoxsuprine has been shown to prevent necrosis and increase survival of skin flaps in the rat, muscle flaps in the rabbit and myocutaneous flaps in the pig (
Finseth and Adelberg, 1978
; Finseth and Adelberg, 1979
; Finseth et al., 1979
; Finseth and Zimmermann, 1979
). It is a long acting vasodilator drug from beta-adrenergic receptor stimulation and possibly has a direct relaxation effect on vascular smooth muscle. In all these experiments, isoxsuprine was given for two weeks prior to raising the flaps. This arbitrary selection of a two week period was based on the assumption that increased flap survival required sustained vasodilation over some definite time period and that this was the basic microcirculatory mechanism responsible for the “delay phenomenon” (Finseth and Adelberg, 1978
, Finseth and Adelberg, 1979
). This experiment was designed to determine the time period necessary to obtain the maximum effect of isoxsuprine in preventing flap necrosis.References
- Prevention of skin flap necrosis by a course of treatment with vasodilator drugs.Plastic and Reconstructive Surgery. 1978; 61: 738
- Experimental work with isoxsuprine for prevention of skin flap necrosis and for treatment of the failing flap.Plastic and Reconstructive Surgery. 1979; 63: 19
- Prevention of necrosis in island myocutaneous flaps in the pig by treatment with isoxsuprine.Plastic and Reconstructive Surgery. 1979; 64: 536
- Prevention of muscle necrosis in an experimental neurovascular island muscle flap by a vasodilator drug - isoxsuprine.Plastic and Reconstructive Surgery. 1979; 63: 774
- An experimental neurovascular skin island flap for the study of the delay phenomenon.Plastic and Reconstructive Surgery. 1978; 61: 412
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© 1980 The Trustees of British Association of Plastic Surgeons. All rights reserved. Published by Elsevier Inc.
