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Research Article| Volume 46, ISSUE 2, P132-135, January 1993

A comparison of newborn versus old skin fibroblasts, their potential for tissue repair

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      Abstract

      An assessment was made of the ability of human skin fibroblasts from newborn and old subjects to produce intracellular urokinase inhibitor and urokinase-plasminogen activator when exposed to phorbol myristate acetate. Urokinase inhibitor produced by human skin fibroblasts may be essential for cell growth regulation. The expression of urokinase inhibitor and/or urokinase-plasminogen activator may possibly be age-related. The principal observation that newborn skin fibroblasts show a low level and poorly sustained production of intracellular inhibitors of urokinase could help to explain the flexibility of the wound healing process in the foetus.

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