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From a drug delivery system using silicone gel, the amount of Ofloxacin (OFLX) released or transferred to a wound and blood was measured over 2 weeks. From three types of silicone gel containing 2, 0.2 and 0.02% OFLX respectively, levels from that with 2% OFLX were highest, approximately two to five times higher than that with 0.02% OFLX. Statistically significant differences were found between the three types (P < 0.01, Student's t-test).
When used in partial thickness skin wounds on rats, only an extremely small amount of OFLX was detected in the serum, being higher under gel containing 2% OFLX. In a clinical study, however, no drug was detected either in the blood or the wound after 1 week.
- Silicone gel including antimicrobial agent.Br J Plast Surg. 1990; 43: 78-82
- A new system of treating wounds by a continuous topical application of medication.Br J Plast Surg. 1990; 43: 83-87
- A silicone gel sheet dressing containing an antimicrobial agent for split thickness donor site wounds.Br J Plast Surg. 1990; 43: 88-93
- Treatment of dermal depth burn wounds with an antimicrobial agent-releasing silicone gel sheet.Burns. 1990; 16: 347-352
- Experiences using silicone gel tie-over dressing following skin grafting.Burns. 1990; 16: 353-357
- Cause of closed suction drainage tube obstruction and its prevention using a tube coated on the inside with a silicone gel drug delivery system.Br J Plast Surg. 1991; 44: 589-592
- The relationship between Prostaglandin E1 applied area and flap survival rate.Br J Plast Surg. 1992; 45: 465-468
- The effect of continuous topical application of heparin on flap survival.Br J Plast Surg. 1992; 45: 515-518
- Determination of ofloxacin in bronchoalveolar fluid by high-performance liquid chromatography and fluorimetric detection.J Chromatogr. 1989; 495: 354-357
- A dermatome for experiments with small animals.Eur J Plast Surg. 1989; 12: 143-144
Accepted: May 19, 1993
Received: March 26, 1992
© 1993 The British Association of Plastic Surgeons. Published by Elsevier Inc.