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Abstract
From a drug delivery system using silicone gel, the amount of Ofloxacin (OFLX) released or transferred to a wound and blood was measured over 2 weeks. From three types of silicone gel containing 2, 0.2 and 0.02% OFLX respectively, levels from that with 2% OFLX were highest, approximately two to five times higher than that with 0.02% OFLX. Statistically significant differences were found between the three types (P < 0.01, Student's t-test).
When used in partial thickness skin wounds on rats, only an extremely small amount of OFLX was detected in the serum, being higher under gel containing 2% OFLX. In a clinical study, however, no drug was detected either in the blood or the wound after 1 week.
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Article info
Publication history
Accepted:
May 19,
1993
Received:
March 26,
1992
Identification
Copyright
© 1993 The British Association of Plastic Surgeons. Published by Elsevier Inc.
