Research Article| Volume 40, ISSUE 2, P188-192, March 1987

Experimental microarterial grafts: freeze-dried heterografts versus autografts

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      Segments of the femoral artery from New Zealand white rabbits were removed and freeze-dried. They were then used as a graft for a defect in the femoral artery of a Sprague-Dawley rat. The femoral artery on the other side of this recipient rat had a similar grafting procedure using a segment of its own femoral artery, thus acting as a control. The patency rate of the freeze-dried heterografts was comparable to the autografts, but the former showed a high incidence of aneurysm formation as a result of immune rejection as supported by histopathological and scanning electron microscopy studies.


        • Alpert B.S.
        • Buncke H.J.
        • Brownstein M.
        Replacement of damaged arteries and veins with vein grafts when replanting crushed, amputated fingers.
        Plastic and Reconstructive Surgery. 1978; 61: 17
        • Caffee H.H.
        Microvascular synthetic grafts.
        Plastic and Reconstructive Surgery. 1980; 66: 380
        • Chow S.P.
        • So Y.C.
        • Chan C.W.
        Experimental microarterial grafts: freeze-dried allografts versus autografts.
        British Journal of Plastic Surgery. 1983; 36: 345
        • Chow S.P.
        • Yang K.F.
        • Luk D.K.
        • So Y.C.
        Experimental microarterial grafts: the use of freeze-dried human placental vessels as heterografts.
        Plastic and Reconstructive Surgery. 1985; 75: 703
        • Das S.K.
        • O'Brien B.McC.
        • Browning F.S.C.
        • Nicholls B.W.G.
        • Nightingale G.
        Segmental microvenous graft to artery.
        British Journal of Plastic Surgery. 1980; 33: 365
        • Gould J.S.
        • Gould S.H.
        • Caudill-Babkes E.L.
        Interpositional microvascular vein grafting.
        Hand. 1979; 11: 332
        • Harashina T.
        Arterial allografts and heterografts in microvascular surgery.
        British Journal of Plastic Surgery. 1978; 31: 16
        • Moore T.C.
        • Riberi A.
        • Kajikuri H.
        Freeze-dried and alcohol preserved homografts for replacement of small arteries.
        Surgery, Gynecology and Obstetrics. 1956; 103: 155
        • O'Brien B.McC.
        • Browning F.S.C.
        • Rosen P.
        Experimental micro-arterial grafts to small arteries.
        British Journal of Plastic Surgery. 1979; 32: 155
        • O'Brien B.McC.
        • Haw C.
        • Kubo T.
        • Gilbert A.
        • Hayhurst J.W.
        Microvenous grafting of small vein defects.
        British Journal of Plastic Surgery. 1979; 32: 164