This paper is only available as a PDF. To read, Please Download here.
Abstract
The importance of heparinised saline irrigation of the vessel ends in microvascular anastomoses may be under-estimated. Recent thrombosis research is reviewed which suggests that heparin is selectively adsorbed onto endothelium, thereby preventing thrombus formation. This evidence is invoked to explain the results of a free flap experiment in the rat and to make some practical recommendations.
Reference
- Binding of human thrombin to human endothelial cells and platelets.Blood. 1975; 46: 1046
- Little Brown and Company, Boston1978 Reconstructive Microsurgery.
- Effect of heparin and thrombin on platelet adherence to the surface of rabbit aorta.Thrombosis Research. 1978; 13: 69
- Binding of heparin on the surface of cultured human endothelial cells.Thrombosis Research. 1978; 12: 773
- An experimental study of microvascular technique, patency rates and related factors.British Journal of Plastic Surgery. 1975; 28: 128
- The observation of heparin on endothelium after injection.Thrombosis Research. 1976; 8: 195
- Low doses of heparin in prevention of deep vein thrombosis.Lancet. 1971; ii: 7726
- Experimental transfer of composite free flaps with microvascular anastomoses.Australian and New Zealand Journal of Surgery. 1973; 43: 285
- Churchill Livingstone, Edinburgh1977 Microvascular Reconstructive Surgery.
- The role of venous endothelium in the inception of thrombosis.Annals of Surgery. 1952; 136: 422
- Transfer of a composite graft with immediate suture anastomosis of its vascular pedicle measuring less than 1 mm in external diameter using microsurgical techniques.Plastic and Reconstructive Surgery. 1967; 40: 325
Article info
Footnotes
This work was carried out in the Christchurch Clinical School, New Zealand, with a grant from the Canterbury Medical Research Foundation and financial assistance from the North Canterbury Hospital Board.
Identification
Copyright
© 1980 The Trustees of British Association of Plastic Surgeons. All rights reserved. Published by Elsevier Inc.