Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 63, Issue 4 , Pages 610-615 , April 2010

Giant naevus, giant excision, eleg(i)ant closure? Reconstructive surgery with Integra Artificial Skin® to treat giant congenital melanocytic naevi in children

  • C. Schiestl

      Affiliations

    • Equal contribution of both authors.
    • ,
  • D. Stiefel

      Affiliations

    • Corresponding Author InformationCorresponding author Tel.: +41 44 266 71 11; Fax: +41 44 266 71 71.
    • Equal contribution of both authors.
    • ,
  • M. Meuli

Received 12 October 2008 ,Accepted 27 January 2009.

References 

  1. Ceballos PI, Ruiz-Maldonado R, Mihm MC. Melanoma in children. N Engl J Med. 1995;332:656–662
  2. Karvonen S-L, Vaajalathi P, Marenk M, et al. Birthmarks in 4346 Finnish newborns. Acta Derm Venereol (Stockh). 1992;72:55–57
  3. Arneja JS, Gosain AK. Giant congenital melanocytic nevi. Plast Reconstr Surg. 2007;120/2:26e–40e
  4. Marghoob AA, Schoenbach SP, Kopf AW, et al. Large congenital melanocytic nevi and the risk for the development of malignant melanoma: a prospective study. Arch Dermatol. 1996;132:170–175
  5. Zutt M, Kretschmer L, Emmert S, et al. Multicentric malignant melanoma in a giant melanocytic congenital nevus 20 years after dermabrasion in adulthood. Dermatol Surg. 2003;29:99–101
  6. Michel JL, Halencon F, Gentil-Perret , et al. Le naevus pigmentaire congénital: pronostic, possibilités thérapeutiques. Arch Pediatr. 1999;6:211–217
  7. Marghoob AA. Congenital melanocytic nevi; evaluation and management. Dermatol Clin. 2002;20:607–616
  8. Abai B, Thayer D, Glat PM. The use of a dermal regeneration template (Integra) for acute resurfacing and reconstruction of defects created by excision of giant hairy nevi. Plast Reconstr Surg. 2004;114/1:162–168
  9. Bittencourt FV, Marghoob AA, Kopf AW, et al. Large congenital melancytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis. Pediatrics. 2000;106/4:736–741
  10. Egan CL, Oliveria SA, Elenitsas R, et al. Cutaneous melanoma risk and phenotypic changes in large congenital nevi: a follow-up study of 46 patients. J Am Acad Dermatol. 1998;39:923–932
  11. Kopp J, Noah EM, Rübben A, et al. Radical resection of giant congenital melanocytic nevus and reconstruction with meek-graft covered Integra dermal template. Dermatol Surg. 2003;29/6:653
  12. Lawrence CM. Treatment options for giant congenital naevi. Clin Exp Dermatol. 2000;25:7–11
  13. Lorentzen M, Pers M, Bretteville-Jensen G. The incidence of malignant transformation in giant pigmented nevi. Scand J Plast Reconstr Surg Hand Surg. 1977;11:163–167
  14. Hale EK, Stein J, Ben-Porat L, et al. Association of melanoma and neurocutaneous melancytosis with large congenital melanocytic naevi – results from the NYU-LCMN registry. Br J Dermatol. 2005;152:512–517
  15. Swetter SM. Dermatological perspectives of malignant melanoma. Surg Clin North Am. 2003;83:77–95
  16. Kruk-Jeromin J, Lewandiwicz E, Rykala J. Surgical treatment of pigmented melanocytic nevi depending upon their size and location. Acta Chir Plast. 1999;41/1:20–24
  17. Soejima K, Nozaki M, Sasaki K, et al. Treatment of giant pigmented nevus using artificial dermis and secondary skin graft from the scalp. Ann Plast Surg. 1997;39/5:489–494
  18. Krengel S, Hauschild A, Schäfer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol. 2006;155/1:1–8
  19. Argenta LC, Morykwas MJ. Vacuum-assisted closure, a new method for wound control and treatment: clinical experience. Ann Plast Surg. 1997;38(6):563–577
  20. Stiefel D, Schiestl C, Meuli M. The positive effect of negative pressure: vacuum assisted fixation of Integra Artificial Skin® for reconstructive surgery in children. J Pediatr Surg, in press.
  21. Dantzer E, Braye FM. Reconstructive surgery using artificial dermis (Integra): results with 39 grafts. J Plast Reconstr Aesthet Surg. 2001;54:659–664
  22. Heimbach D, Warden G, Luterman A, et al. Multicenter postapproval clinical trial of Integra® dermal regeneration template for burn treatment. J Burn Care Res. 2003;24/1:42
  23. Moiemen NS, Vlachou E, Staiano JJ, et al. Reconstructive surgery with Integra dermal regeneration template: histologic study, clinical evaluation, and current practice. Plast Reconstr Surg. 2006;117:160S–174S
  24. Groos N, Guillot M, Zilliox , et al. Use of artificial dermis (Integra) for the reconstruction of extensive burn scars in children. Eur J Pediatr Surg. 2005;15:187–192
  25. Moiemen NS, Staiano JJ, Nkemcho OO, et al. Reconstructive surgery with a dermal regeneration template: clinical and histologic study. Plast Reconst Surg. 2000;108:93–103
  26. Dragieva G, Hafner J, Künzi W, et al. Malignant melanoma in a giant congenital melanocytic naevus 9 years after dermabrasion in childhood. J Dermatol. 2006;121:208–209
  27. Bett BJ. Large or multiple congenital melanocytic nevi: occurrence of neurocutaneous melanocytosis in 1008 persons. J Am Acad Dermatol. 2006;54:767–777

☆ Parts of the data were presented at: 65th Annual Meeting of the German Society für Paediatric Oncology and Haematology, Germany, Stuttgart, June 17–18 2005. XIIIth Congress of the International Society for Burn Injuries, Brazil, Fortaleza September 24–29, 2006. 25th Annual Meeting of the German-speaking Society for Burn Injuries (deutschsprachige Arbeitsgemeinschaft für Verbrennungsmedizin), Austria, St. Anton, January 10–13, 2007.

PII: S1748-6815(09)00141-7

doi: 10.1016/j.bjps.2009.01.050

Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 63, Issue 4 , Pages 610-615 , April 2010

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