Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 61, Issue 12 , Pages 1421-1422 , December 2008

RDEB: regeneration is not enough

References 

  1. Burgeson RE, Christiano AM. The dermal-epidermal junction. Curr Opin Cell Biol. 1997;9:651–658
  2. Dang N, Murrell DF. Mutation analysis and characterization of COL7A1 mutations in dystrophic epidermolysis bullosa. Exp Dermatol. 2008;17:553–568
  3. Woodley DT, Hou Y, Martin S, et al. Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesis. J Biol Chem. 2008;283:17838–17845
  4. Mallipeddi R. Epidermolysis bullosa and cancer. Clin Exp Dermatol. 2002;27:616–623
  5. Mavilio F, Pellegrini G, Ferrari S, et al. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med. 2006;12:1397–1402
  6. Falabella AF, Valencia IC, Eaglstein WH, et al. Tissue-engineered skin (Apligraf) in the healing of patients with epidermolysis bullosa wounds. Arch Dermatol. 2000;136:1225–1230
  7. Goto M, Sawamura D, Ito K, et al. Fibroblasts show more potential as target cells than keratinocytes in COL7A1 gene therapy of dystrophic epidermolysis bullosa. J Invest Dermatol. 2006;126:766–772
  8. Chen M, Woodley DT. Fibroblasts as target cells for DEB gene therapy. J Invest Dermatol. 2006;126:708–710
  9. Wong T, Gammon L, Liu L, et al. Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2008;128:2179–2189
  10. Uitto J. Epidermolysis bullosa: prospects for cell-based therapies. J Invest Dermatol. 2008;128:2140–2142
  11. Marionnet C, Pierrard C, Vioux-Chagnoleau C, et al. Interactions between fibroblasts and keratinocytes in morphogenesis of dermal epidermal junction in a model of reconstructed skin. J Invest Dermatol. 2006;126:971–979
  12. Jiang QJ, Uitto J. Animal models of epidermolysis bullosa – targets for gene therapy. J Invest Dermatol. 2005;124:xi–xiii
  13. Heinonen S, Mannikko M, Klement JF, et al. Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa. J Cell Sci. 1999;112:3641–3648
  14. Fritsch A, Loeckermann S, Kern JS, et al. A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest. 2008;118:1669–1679
  15. Burd A. Salamanders, lizards and ubiquitous stem cells. J Plast Reconstr Aesthet Surg. 2008;61:121–123

PII: S1748-6815(08)01030-9

doi: 10.1016/j.bjps.2008.10.008

Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 61, Issue 12 , Pages 1421-1422 , December 2008

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