Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 61, Issue 3 , Pages 245-249 , March 2008

Immunosuppression in an emerging field of plastic reconstructive surgery: composite tissue allotransplantation

  • H. Madani

      Affiliations

    • Department of Plastic Surgery, Royal Free Hospital, London NW3 2QG, UK
    • Corresponding Author InformationCorresponding author. Address: Department of Plastic Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK. Tel.: +44 (0)207 472 6184; fax: +44 (0)207 472 6557.
  • ,
  • S. Hettiaratchy

      Affiliations

    • Department of Plastic Surgery, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK
  • ,
  • A. Clarke

      Affiliations

    • Department of Plastic Surgery, Royal Free Hospital, London NW3 2QG, UK
  • ,
  • P.E.M. Butler

      Affiliations

    • Department of Plastic Surgery, Royal Free Hospital, London NW3 2QG, UK

Received 26 November 2006 ,Accepted 17 October 2007.

References 

  1. Butler PE, Clarke A, Hettiaratchy S. Facial transplantation. A new option in reconstruction of severe facial injury. BMJ. 2005;331:1349–1350
  2. Devauchelle B, Badet L, Lengele B, et al. First human face allograft: early report. Lancet. 2006;368:203–209
  3. Macartney J. Face transplant for bear attack victim. Times (Lond). April 15, 2006;http://www.timesonline.co.uk/article/0, 25689–2135297, 00.html(accessed Sept 21, 2006)
  4. Hettiaratchy S, Butler PE. Extending the boundaries of transplantation. BMJ. 2003;326:1226–1227
  5. Hettiaratchy S, Randolph MA, Petite F, et al. Composite tissue allotransplantation: a new era in plastic surgery?. Br J Plast Surg. 2004;57:381–391
  6. Clarke A, Butler PE. Facial transplantation: adding to the reconstructive options after severe facial injury and disease. Expert Opin Biol Ther. 2005;5:1539–1546
  7. Hettiaratchy S, Butler PE. Facial transplantation – fantasy or the future?. Lancet. 2002;360:5–6
  8. Butler PE, Hettiaratchy S, Clarke A. Managing the risks of facial transplantation. Lancet. 2006;368:561–563
  9. Brouha P, Naidu D, Cunningham M, et al. Risk acceptance in composite-tissue allotransplantation reconstructive procedures. Microsurgery. 2006;26:144–149discussion 149–50
  10. Lee WPA, Yaremchuk MJ, Pan YC, et al. Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg. 1991;87:401–411
  11. Gorantla VS, Barker JH, Jones JW, et al. Immunosuppressive agents in transplantation: mechanisms of action and current anti-rejection strategies. Microsurgery. 2000;20:420–429
  12. Cendales L, Hardy MA. Immunological considerations in composite tissue transplantation: overview. Microsurgery. 2002;20:412–419
  13. In:  Rubin RH,  Young LS editor. Clinical Approach to Infection in the Immunocompromised Host. 3rd ed.. New York: Plenum Press; 1994;
  14. Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med. 1998;338:1741–1751
  15. Shapiro R, Fung JJ, Jain AB, et al. The side effects of FK 506 in humans. Transplant Proc. 1990;264:63–67
  16. Sratta RJ for the FK/MMF Multi-Center Study Group. Simultaneous use of tacrolimus and mycophenolate mofetil in combined pancreas—kidney transplant recipients: a multi-center report. Transplant Proc. 1997;29:654–655
  17. Gander B, Brown CS, Vasilic D. Composite tissue allotransplantation of the hand and face: a new frontier in transplant and reconstructive surgery. Transpl Int. 2006;19:868–880
  18. Schulak JA. Steroid immunosuppression in kidney transplantation: a passing era. J Surg Reas. 2004;117:154–162
  19. Veenstra DL, Best JH, Hornberger J. Incidence and long-term cost of steroid-related side effects after renal transplantation. Am J Kidney Dis. 1999;33:829–839
  20. Clavijo-Alvarez JA, Hamad GG, Taieb A, et al. Pharmacologic approaches to composite tissue allograft. J Hand Surg. 2007;32:104–118
  21. First MR, Peddi VR. Malignancies complicating organ transplantation. Transplant Proc. 1998;30:2768–2770
  22. Sheil AGR, Disney APS, Mathew TH, et al. Cancer development in cadaveric donor renal allograft recipients treated with azathioprine (AZA) or cyclosporine (CsA) or AZA/CsA. Transplant Proc. 1991;23:1111–1112
  23. Baumeister S, Kleist C, Dohler B, et al. Risks of allogeneic hand transplantation. Microsurgery. 2004;24:98–103
  24. Jones NF. Concerns about human hand transplantation in the 21st century. J Hand Surg [Am]. 2002;27:771–787
  25. Brenner MJ, Tung TH, Jensen JN, et al. The spectrum of complications of immunosuppression: is the time right for hand transplantation?. J Bone Joint Surg Am. 2002;84:1861–1870
  26. Cecka JM, Terasaki PI. The UNOS Scientific Renal Transplant Registry. In:  Terasaki PI,  Cecka JM editor. Clinical Transplants 1994. Los Angeles: UCLA Tissue Typing Laboratory; 1994;p. 1–18
  27. Tejani A, Sullivan EK. The impact of acute rejection on chronic rejection: a report of the North American Paediatric Renal Transplant Cooperative Study. Paediatr Transplant. 2000;4:107–111
  28. Kahan BD. Potential therapeutic interventions to avoid or treat chronic allograft dysfunction. Transplantation. 2001;71:S52–S57
  29. Krieger NR, Emre S. Novel immunosuppressants. Paediatr Transplant. 2004;8:594–599
  30. Lima RS, Nogueira-Martins MF, Silva HT, et al. FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination. Transplant Proc. 2004;36:1015–1017
  31. Kahan BD. Sirolimus: a ten-year perspective. Transplant Proc. 2004;36:71–75
  32. Ayrout C, Lanzetta M, Chunasuwankul R, et al. Experimental limb transplantation, part I: identification of an effective tapered triple combination immunosuppressive regime. Transplant Proc. 2004;36:669–674
  33. Ringe B, Braun F, Lorf T, et al. Tacrolimus and mycophenolate mofetil in clinical liver transplantation: experience with a steroid-sparing concept. Transplant Proc. 1998;30:1415–1416
  34. Fujita T, Takahashi S, Yagihashi A, et al. Prolonged survival of rat skin allograft by treatment with FK506 ointment. Transplantation. 1997;64:922–925
  35. Gruber SA, Shirbacheh MV, Jones JW, et al. Local drug delivery to composite tissue allografts. Microsurgery. 2000;20:407–411
  36. Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation. 1995;59:256–262
  37. Schwarze ML, Menard MT, Fuchimoto Y, et al. Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine. Ann Thorac Surg. 2000;70:131–139
  38. Huang C, Fuchimoto Y, Scheier-Dolberg R, et al. Stable mixed-chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model. J Clin Invest. 2000;105:173–181
  39. Lee WP, Rubin JP, Bourget JL, et al. Tolerance to limb tissue allografts between swine matched for major histocompatibility complex antigens. Plast Reconstr Surg. 2001;107:1482–1490discussion 1491–2
  40. Butler PE, Lee WP, van de Water AP, et al. Neonatal induction of tolerance to skeletal tissue allografts without immunosuppression. Plast Reconstr Surg. 2000;105:2424–2430discussion 2431–2
  41. Cober SR, Randolph MA, Lee WP. Skin allograft survival following intrathymic injection of donor bone marrow. J Surg Res. 1999;85:204–208
  42. Tai C, Goldenberg M, Schuster KM, et al. Composite tissue allotransplantation. J Inv Surg. 2003;16:193–201
  43. Hettiaratchy S, Melendy E, Randolph MA, et al. Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation. 2004;77:514–521
  44. Seimionow M, Ortak T, Izycki D, et al. Induction of tolerance in composite-tissue allografts. Transplantation. 2002;74:1211–1217
  45. Siemionow M, Zieliniski M, Ozmen S, et al. Intraosseus transplantation of donor-derived hematopoietic stem and progenitor cells induces donor-specific chimerism and extends composite tissue allograft survival. Transplantation Proc. 2005;37:2303–2308
  46. Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002;30:42–48
  47. Siemionow M, Agaoglu G. Tissue transplantation in plastic surgery. Clin Plastic Surg. 2007;34:251–269
  48. Kanitakis J, Jullien D, Petruzzo P, et al. Clinicopathologic features of graft rejection of the first human hand allograft. Transplantation. 2003;76:688–693
  49. Lanzetta M, Petruzzo P, Vitale G, et al. Human hand transplantation: what have we learned?. Transplant Proc. 2004;36:664–668
  50. Stark GB, Swartz WM, Narayanan K, et al. Hand transplantation in baboons. Transplant Proc. 1987;19:3968–3971
  51. Hovius SER, Stevens HPJD, Van Nierop PWM. Allogenic transplantation of the radial side of the hand in the rhesus monkey. Plast Reconstr Surg. 1992;89:700–709
  52. Petit F, Minns AB, Dubernard JM, et al. Composite tissue allotransplantation and reconstructive surgery: first clinical applications. Ann Surg. 2003;11:1–6
  53. Dubernard JM, Burloux G, Giraux P, et al. Three lessons learned from the first double hand transplantation. Bull Acad Natl Med. 2002;186:1051–1062
  54. Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft: report on first 6 months. Lancet. 1999;353:1315–1320
  55. Selvaggi G, Levi DM, Kato T, et al. Expanded use of transplantation techniques: abdominal wall transplantation and intestinal autotransplantation. Transplant Proc. 2004;36:1561–1563

PII: S1748-6815(07)00565-7

doi: 10.1016/j.bjps.2007.10.048

Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 61, Issue 3 , Pages 245-249 , March 2008