Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 60, Issue 8 , Pages 861-863 , August 2007

Effects of clopidogrel on survival of rat skin flaps

  • Atilla Ersoy

      Affiliations

    • Iskenderun Government Hospital, Plastic Surgery Department, Iskenderun, Turkey
    • ,
  • Kutlu Sevin

      Affiliations

    • Ankara University Faculty of Medicine, Plastic and Reconstructive Surgery Department, Ankara, Turkey
    • ,
  • Asuman Sevin

      Affiliations

    • Ankara Numune Training and Research Hospital, Plastic and Reconstructive Surgery Department, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Ankara Numune Training and Research Hospital, Plastic and Reconstructive Surgery Department, Zirvekent 2. Etap Sitesi C-1/43 Cankaya, Ankara 06550, Turkey. Tel.: +90 532 274 4366; fax: +90 312 495 5990.
    • ,
  • Savaş Serel

      Affiliations

    • Ankara University Faculty of Medicine, Plastic and Reconstructive Surgery Department, Ankara, Turkey

Received 13 May 2006 ,Accepted 5 February 2007.

References 

  1. Bernat A, Mares AM, Defreyn G, et al. Effect of various antiplatelet agents on acute arterial thrombosis in the rat. Thromb Haemost. 1993;70:812–816
  2. Herault JP, Dol F, Gaich C, et al. Effect of clopidogrel on thrombin generation in platelet-rich plasma in the rat. Thromb Haemost. 1999;81:957–960
  3. Ghavami A, Nutt MP, Hardy SP. Heat shock protein and high-dose aspirin: effects on random skin flap survival in a rat model. Ann Plast Surg. 2002;48:60–67
  4. Yoshida WB, Campos EB. Ischemia and reperfusion in skin flaps: effects of mannitol and vitamin C in reducing necrosis area in a rat experimental model. Acta Cir Bras. 2005;20:358–363
  5. Tyner TR, Russell D, Yamaguchi KT. Effects of lipoic acid and a reduced-calorie diet on skin flap survival in a rat model. Plast Reconstr Surg. 2004;114:1980–1982
  6. Tyner TR, Shahbazian R, Nakashima J, et al. Propofol improves skin flap survival in a rat model: correlating reduction in flap-induced neutrophil activity. Ann Plast Surg. 2004;53:273–277
  7. Akan M, Cakir B, Misirlioglu A, et al. Effects of clopidogrel and high dose aspirin on survival of skin flaps in rats. Scand J Plast Reconstr Surg Hand Surg. 2005;39:7–10
  8. Finseth F, Cutting C. An experimental neurovascular island skin flap for the study of the delay phenomenon. Plast Reconstr Surg. 1978;61:412–420
  9. Kerrigan CL, Daniel RK. Pharmacologic treatment of the failing skin flap. Plast Reconstr Surg. 1982;70:541–548
  10. Reinisch RF. The pathophysiology of skin flap circulation. Plast Reconstr Surg. 1974;54:585–598
  11. Kerrigan CL. Skin flap failure: pathophysiology. Plast Reconstr Surg. 1983;72:766–777
  12. Donavan WE. Experimental model in skin flap research. In:  Grabb WC,  Myers MB editor. The Skin Flaps. Boston: Little, Brown; 1975;p. 11–20
  13. Herbert JM, Bernat A, Maffrand JP. Importance of platelets in experimental venous thrombosis in the rat. Blood. 1992;80:2281–2286
  14. Savi P, Herbert JM, Pflieger AM, et al. Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel. Biochem Pharmacol. 1992;44:527–532
  15. Matsagas M, Jagroop IA, Geroulakos G, et al. The effect a loading dose (300mg) of clopidogrel on platelet function in patients with peripheral arterial disease. Clin Appl Thromb Hemost. 2003;9:115–120

PII: S1748-6815(07)00119-2

doi: 10.1016/j.bjps.2007.02.001

Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 60, Issue 8 , Pages 861-863 , August 2007

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