Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 60, Issue 1 , Pages 64-72 , January 2007

Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-β receptor II

  • Russell R. Reid

      Affiliations

    • Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 675 North Saint Clair, Suite 19-250, Chicago, IL 60611, USA
    • ,
  • Nakshatra Roy

      Affiliations

    • Department of Surgery, Wound Healing Research Lab, Northwestern University, 300 East Superior Street, Room 4-720, Chicago, IL 60611, USA
    • ,
  • Jon E. Mogford

      Affiliations

    • Department of Surgery, Wound Healing Research Lab, Northwestern University, 300 East Superior Street, Room 4-720, Chicago, IL 60611, USA
    • ,
  • Hannah Zimmerman

      Affiliations

    • Department of Surgery, Wound Healing Research Lab, Northwestern University, 300 East Superior Street, Room 4-720, Chicago, IL 60611, USA
    • ,
  • Chung Lee

      Affiliations

    • Department of Urology, Northwestern University, 300 East Superior Street, 11-715 CHT 229, Chicago, IL 60611, USA
    • ,
  • Thomas A. Mustoe

      Affiliations

    • Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 675 North Saint Clair, Suite 19-250, Chicago, IL 60611, USA
    • Corresponding Author InformationCorresponding author. Division of Plastic Surgery, Department of Surgery, Feinberg School of Medicine, Northwestern University, 675 North Saint Clair, Suite 19-250, Chicago, IL 60611, USA. Tel.: +1 312 695 6022; fax: +1 312 695 5672.

Received 5 February 2005 ,Accepted 7 December 2005.

References 

  1. Schmid P, Itin P, Cherry G, et al. Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar. Am J Pathol. 1998;152(2):485–493
  2. Qi Z, Atsuchi N, Ooshima A, et al. Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci USA. 1999;96(5):2345–2349
  3. Cosgrove D, Rodgers KD, Meehan DT, et al. Integrin [alpha]1[beta]1 and TGF-[beta]1 play distinct roles in Alport glomerular pathogenesis and serve as dual targets for metabolic therapy. Am J Pathol. 2000;157:1649–1659
  4. Morris DD, Zhao LL, Bolton L, et al. Acute and chronic models for excessive dermal scarring: quantitative studies. Plast Reconstr Surg. 1997;100(3):674–681
  5. Saulis A, Chao J, Telser A, et al. Silicone occlusive treatment of hypertrophic scars in the rabbit hypertrophic scar model. Aesthetic Surg J. 2002;22:147–153
  6. Kim I, Mogford JE, Witschi C, et al. Inhibition of prolyl 4-hydroxylase reduces scar hypertrophy in a rabbit model of cutaneous scarring. Wound Repair Regen. 2003;11(5):368–372
  7. Reid RR, Mogford JE, Butt R, et al. Inhibition of procollagen C- proteinase reduces scar hypertrophy in a rabbit model of cutaneous scarring. Wound Repair Regen, in press.
  8. Marcus JR, Tyrone JW, Bonomo S, et al. Cellular mechanisms for diminished scarring with aging. Plast Reconstr Surg. 2000;105:1591–1599
  9. Kundu SD, Kim IY, Yang T, et al. Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying the C3(I)-TGF-b type II dominant negative receptor. Prostate. 2000;43:118–124
  10. Lu L, Saulis AS, Liu WR, et al. The temporal effects of TGF-beta 1, 2 and 3 monoclonal antibody on wound healing and hypertrophic scar formation. J Am Coll Surg. 2005;201(3):391–397
  11. Andree C, Swain WF, Page CP, et al. In vivo transfer and expression of human epidermal growth factor gene accelerates wound repair. Proc Natl Acad Sci U S A. 1994;91:12188–12192
  12. Eickelberg O. Endless healing: TGFb, SMADs, and fibrosis. FEBS Lett. 2001;506:11–14
  13. Eming SA, Medalie DA, Tompkins RG, et al. Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft. Hum Gene Ther. 1998;9:529–539
  14. Lee MJ, Roy NK, Mogford JE, et al. Fibulin-5 promotes wound healing in vivo. J Am Coll Surg. 2004;199(3):403–410
  15. Ferber D. Gene therapy: safer and virus-free?. Science. 2001;294:1638–1642
  16. Hijjawi J, Mogford JE, Chandler LA, et al. Platelet-derived growth factor B, but not fibroblast growth factor 2, plasmid DNA improves survival of ischemic myocutaneous flaps. Arch Surg. 2004;139(2):142–147
  17. Doukas J, Chandler LA, Gonzalez AM, et al. Matrix immobilization enhances the tissue repair activity of growth factor gene therapy vectors. Hum Gene Ther. 2001;12:783–798
  18. Liu W, Chua C, Wu X, et al. Inhibiting scar formation in rat wounds by adenovirus-mediated overexpression of truncated TGF-b receptor II. Plast Reconstr Surg. 2005;115(3):865–870

☆ Presented at the 14th Annual Wound Healing Society Meeting, Atlanta, GA, 2004.

PII: S1748-6815(06)00152-5

doi: 10.1016/j.bjps.2005.12.026

Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume 60, Issue 1 , Pages 64-72 , January 2007

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